Campylobacter jejuni Infections: Epidemiology, Pathophysiology, Clinical Manifestations and Management

Rozan O Al-Khreshieh*; Ola Al-Fawares; Abu-Taleb EM

**Rozan O Al-Khreshieh*, Ola Al-Fawares and Abu-Taleb EM**

Volume4-Issue2
Dates: Received: 2023-02-11 | Accepted: 2023-02-21 | Published: 2023-02-22
Pages: 258-269

Abstract

Campylobacter spp has become one of the most important foodborne pathogens. Moreover, Campylobacter can cause an economic burden on the human population since it can cause about 8.4% of diarrheal cases worldwide. In addition, Campylobacteriosis outbreaks have been reported sporadically in association with untreated drinking water. Water that does not take from a licensed water supplier is considered the main cause of water contamination. The most common risk factor for Campylobacteriosis transmission to humans is raw undercooked chicken. Contamination among poultry may be the result of the environmental conditions inside the farms or chicken factories that could be spread very fast among others. This infection is usually self-limited with no signs or symptoms but it can also present with severe symptoms, including diarrhea that can last for more than one week and can ultimately lead to dehydration, fever, and abdominal pain. However, the main recognized sequelae are Guillain-Barré Syndrome (GBS), Reactive Arthritis (REA), Irritable Bowel Syndrome (IBS), and rarely Bacteremia. Recently, many cases of Campylobacter spp show important resistance to various antibiotics such as tetracyclines and fluoroquinolones. Thus, the prevention and monitoring of this infection play an essential role. Campylobacteriosis is self-limiting, and most of the cases does not need to be treated. Some medical interventions such as electrolytes replacement, as well as hydration may be followed to treat immunocompromised patients, patients suffering from severe symptoms, pregnant women, and the elderly.

FullText HTML FullText PDF DOI: 10.37871/jbres1670

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How to cite this article

Al-Khreshieh RO, Al-Fawares O, Abu-Taleb EM. Campylobacter jejuni Infections: Epidemiology, Pathophysiology, Clinical Manifestations and Management. 2023 Feb 22; 4(2): 258-269. doi: 10.37871/jbres1670, Article ID: JBRES1670, Available at: https://www.jelsciences.com/articles/jbres1670.pdf

Subject area(s)

Public Health

References

Facciolà A, Riso R, Avventuroso E, Visalli G, Delia SA, Laganà P. Campylobacter: from microbiology to prevention. J Prev Med Hyg. 2017 Jun;58(2):E79-E92. PMID: 28900347; PMCID: PMC5584092.
Vandamme P. Taxonomy of the family Campylobacteraceae in Campylobacter. American Society for Microbiology. 2000;3-27.
On SL. Taxonomy of Campylobacter, Arcobacter, Helicobacter and related bacteria: current status, future prospects and immediate concerns. Symp Ser Soc Appl Microbiol. 2001;(30):1S-15S. doi: 10.1046/j.1365-2672.2001.01349.x. PMID: 11422556.
Silva J, Leite D, Fernandes M, Mena C, Gibbs PA, Teixeira P. Campylobacter spp. as a Foodborne Pathogen: A Review. Front Microbiol. 2011 Sep 27;2:200. doi: 10.3389/fmicb.2011.00200. PMID: 21991264; PMCID: PMC3180643.
Silva MF, Pereira G, Carneiro C, Hemphill A, Mateus L, Lopes-da-Costa L, Silva E. Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls. PLoS One. 2020 Jan 10;15(1):e0227500. doi: 10.1371/journal.pone.0227500. PMID: 31923228; PMCID: PMC6953823.
Bronowski C, James CE, Winstanley C. Role of environmental survival in transmission of Campylobacter jejuni. FEMS Microbiol Lett. 2014 Jul;356(1):8-19. doi: 10.1111/1574-6968.12488. Epub 2014 Jun 19. PMID: 24888326.
Golz JC, Epping L, Knüver MT, Borowiak M, Hartkopf F, Deneke C, Malorny B, Semmler T, Stingl K. Whole genome sequencing reveals extended natural transformation in Campylobacter impacting diagnostics and the pathogens adaptive potential. Sci Rep. 2020 Feb 28;10(1):3686. doi: 10.1038/s41598-020-60320-y. PMID: 32111893; PMCID: PMC7048796.
Kelley BR, Ellis JC, Large A, Schneider LG, Jacobson D, Johnson JG. Whole-Genome Sequencing and Bioinformatic Analysis of Environmental, Agricultural, and Human Campylobacter jejuni Isolates From East Tennessee. Front Microbiol. 2020 Nov 5;11:571064. doi: 10.3389/fmicb.2020.571064. PMID: 33224113; PMCID: PMC7674308.
Nachamkin I, Nguyen P. Isolation of Campylobacter Species from Stool Samples by Use of a Filtration Method: Assessment from a United States-Based Population. J Clin Microbiol. 2017 Jul;55(7):2204-2207. doi: 10.1128/JCM.00332-17. Epub 2017 May 3. PMID: 28468859; PMCID: PMC5483923.
Kreling V, Falcone FH, Kehrenberg C, Hensel A. Campylobacter sp.: Pathogenicity factors and prevention methods-new molecular targets for innovative antivirulence drugs? Appl Microbiol Biotechnol. 2020 Dec;104(24):10409-10436. doi: 10.1007/s00253-020-10974-5. Epub 2020 Nov 13. PMID: 33185702; PMCID: PMC7662028.
Kassem II, Rajashekara G. An ancient molecule in a recalcitrant pathogen: the contributions of poly-P to the pathogenesis and stress responses of Campylobacter jejuni. Future Microbiol. 2011 Oct;6(10):1117-20. doi: 10.2217/fmb.11.94. PMID: 22004028.
Dasti JI, Tareen AM, Lugert R, Zautner AE, Gross U. Campylobacter jejuni: a brief overview on pathogenicity-associated factors and disease-mediating mechanisms. Int J Med Microbiol. 2010 Apr;300(4):205-11. doi: 10.1016/j.ijmm.2009.07.002. Epub 2009 Aug 8. PMID: 19665925.
Caner V, Cokal Y, Cetin C, Sen A, Karagenc N. The detection of hipO gene by real-time PCR in thermophilic Campylobacter spp. with very weak and negative reaction of hippurate hydrolysis. Antonie Van Leeuwenhoek. 2008 Nov;94(4):527-32. doi: 10.1007/s10482-008-9269-4. Epub 2008 Jul 30. PMID: 18665452.
Reddy S, Zishiri OT. Genetic characterisation of virulence genes associated with adherence, invasion and cytotoxicity in Campylobacter spp. isolated from commercial chickens and human clinical cases. Onderstepoort J Vet Res. 2018 Feb 15;85(1):e1-e9. doi: 10.4102/ojvr.v85i1.1507. PMID: 29781670; PMCID: PMC6238761.
Konkel ME, Klena JD, Rivera-Amill V, Monteville MR, Biswas D, Raphael B, Mickelson J. Secretion of virulence proteins from Campylobacter jejuni is dependent on a functional flagellar export apparatus. J Bacteriol. 2004 Jun;186(11):3296-303. doi: 10.1128/JB.186.11.3296-3303.2004. PMID: 15150214; PMCID: PMC415756.
de Carvalho AF, da Silva DM, Azevedo SS, Piatti RM, Genovez ME, Scarcelli E. Detection of CDT toxin genes in Campylobacter spp. strains isolated from broiler carcasses and vegetables in São Paulo, Brazil. Braz J Microbiol. 2014 Jan 15;44(3):693-9. doi: 10.1590/s1517-83822013000300005. PMID: 24516435; PMCID: PMC3910176.
Guerry P. Campylobacter flagella: not just for motility. Trends Microbiol. 2007 Oct;15(10):456-61. doi: 10.1016/j.tim.2007.09.006. Epub 2007 Oct 24. PMID: 17920274.
Bolton DJ. Campylobacter virulence and survival factors. Food Microbiol. 2015 Jun;48:99-108. doi: 10.1016/j.fm.2014.11.017. Epub 2014 Dec 25. PMID: 25790997.
Guerry P, Poly F, Riddle M, Maue AC, Chen YH, Monteiro MA. Campylobacter polysaccharide capsules: virulence and vaccines. Front Cell Infect Microbiol. 2012 Feb 15;2:7. doi: 10.3389/fcimb.2012.00007. PMID: 22919599; PMCID: PMC3417588.
Al-Khresieh RO, Al-Daghistani HI, Abu-Romman SM, Abu-Niaaj LF. Genetic Signature and Serocompatibility Evidence for Drug Resistant Campylobacter jejuni. Antibiotics (Basel). 2022 Oct 17;11(10):1421. doi: 10.3390/antibiotics11101421. PMID: 36290079; PMCID: PMC9598221.
Igwaran A, Okoh AI. Human campylobacteriosis: A public health concern of global importance. Heliyon. 2019 Nov 14;5(11):e02814. doi: 10.1016/j.heliyon.2019.e02814. PMID: 31763476; PMCID: PMC6861584.
Whiley H, van den Akker B, Giglio S, Bentham R. The role of environmental reservoirs in human campylobacteriosis. Int J Environ Res Public Health. 2013 Nov 8;10(11):5886-907. doi: 10.3390/ijerph10115886. PMID: 24217177; PMCID: PMC3863877.
Forson AO, Adjei DN, Olu-Taiwo M, Quarchie MN, Asmah HR. Characterization of Campylobacter associated gastric enteritis among patients with Human Immunodeficiency Virus (HIV) in a hospital in Accra, Ghana. PLoS One. 2020 Oct 15;15(10):e0240242. doi: 10.1371/journal.pone.0240242. PMID: 33057408; PMCID: PMC7561167.
Battikhi MN. Epidemiological study on Jordanian patients suffering from diarrhoea. New Microbiol. 2002 Oct;25(4):405-12. PMID: 12437219.
Kaakoush NO, Castaño-Rodríguez N, Mitchell HM, Man SM. Global Epidemiology of Campylobacter Infection. Clin Microbiol Rev. 2015 Jul;28(3):687-720. doi: 10.1128/CMR.00006-15. PMID: 26062576; PMCID: PMC4462680.
Larrosa-Haro A, Macias-Rosales R, Sánchez-Ramírez CA, Cortés-López MC, Aguilar-Benavides S. Seasonal variation of enteropathogens in infants and preschoolers with acute diarrhea in western Mexico. J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):534-6. doi: 10.1097/MPG.0b013e3181df5b66. PMID: 20706147.
Havelaar AH, Ivarsson S, Löfdahl M, Nauta MJ. Estimating the true incidence of campylobacteriosis and salmonellosis in the European Union, 2009. Epidemiol Infect. 2013 Feb;141(2):293-302. doi: 10.1017/S0950268812000568. Epub 2012 Apr 13. PMID: 22717051; PMCID: PMC9152072.
Liu F, Lee SA, Xue J, Riordan SM, Zhang L. Global epidemiology of campylobacteriosis and the impact of COVID-19. Front Cell Infect Microbiol. 2022 Nov 28;12:979055. doi: 10.3389/fcimb.2022.979055. PMID: 36519137; PMCID: PMC9742372.
European Food Safety Authority; European Centre for Disease Prevention and Control. The European Union One Health 2020 Zoonoses Report. EFSA J. 2021 Dec 13;19(12):e06971. doi: 10.2903/j.efsa.2021.6971. PMID: 36329690; PMCID: PMC9624447.
Yoshikura H. Declining Vibrio parahaemolyticus and Salmonella, Increasing Campylobacter and Persisting Norovirus Food Poisonings: Inference Derived from Food Poisoning Statistics of Japan. Jpn J Infect Dis. 2020 Mar 24;73(2):102-110. doi: 10.7883/yoken.JJID.2019.247. Epub 2019 Oct 31. PMID: 31666496.
Jackson BR, Zegarra JA, López-Gatell H, Sejvar J, Arzate F, Waterman S, Núñez AS, López B, Weiss J, Cruz RQ, Murrieta DY, Luna-Gierke R, Heiman K, Vieira AR, Fitzgerald C, Kwan P, Zárate-Bermúdez M, Talkington D, Hill VR, Mahon B; GBS Outbreak Investigation Team. Binational outbreak of Guillain-Barré syndrome associated with Campylobacter jejuni infection, Mexico and USA, 2011. Epidemiol Infect. 2014 May;142(5):1089-99. doi: 10.1017/S0950268813001908. Epub 2013 Aug 7. PMID: 23924442; PMCID: PMC6527315.
Zeigler M, Claar C, Rice D, Davis J, Frazier T, Turner A, Kelley C, Capps J, Kent A, Hubbard V, Ritenour C, Tuscano C, Qiu-Shultz Z, Leaumont CF; Centers for Disease Control and Prevention (CDC). Outbreak of campylobacteriosis associated with a long-distance obstacle adventure race--Nevada, October 2012. MMWR Morb Mortal Wkly Rep. 2014 May 2;63(17):375-8. PMID: 24785983; PMCID: PMC4584888.
Scott MK, Geissler A, Poissant T, DeBess E, Melius B, Eckmann K, Salehi E, Cieslak PR; Centers for Disease Control and Prevention (CDC). Notes from the field: campylobacteriosis outbreak associated with consuming undercooked chicken liver pâté - Ohio and Oregon, December 2013-January 2014. MMWR Morb Mortal Wkly Rep. 2015 Apr 17;64(14):399. PMID: 25879900; PMCID: PMC5779543.
Health, disease control and prevention, epidemiology. Communicable disease rule; R386-702. Salt Lake City, UT: Utah Department of Health. 2016.
Haddad N, Marce C, Magras C, Cappelier JM. An overview of methods used to clarify pathogenesis mechanisms of Campylobacter jejuni. J Food Prot. 2010 Apr;73(4):786-802. doi: 10.4315/0362-028x-73.4.786. PMID: 20377972.
Young KT, Davis LM, Dirita VJ. Campylobacter jejuni: molecular biology and pathogenesis. Nat Rev Microbiol. 2007 Sep;5(9):665-79. doi: 10.1038/nrmicro1718. PMID: 17703225.
Chang WS, van de Mortel M, Nielsen L, Nino de Guzman G, Li X, Halverson LJ. Alginate production by Pseudomonas putida creates a hydrated microenvironment and contributes to biofilm architecture and stress tolerance under water-limiting conditions. J Bacteriol. 2007 Nov;189(22):8290-9. doi: 10.1128/JB.00727-07. Epub 2007 Jun 29. PMID: 17601783; PMCID: PMC2168710.
Elgamoudi BA, Korolik V. Campylobacter Biofilms: Potential of Natural Compounds to Disrupt Campylobacter jejuni Transmission. Int J Mol Sci. 2021 Nov 10;22(22):12159. doi: 10.3390/ijms222212159. PMID: 34830039; PMCID: PMC8617744.
Brown HL, Reuter M, Hanman K, Betts RP, van Vliet AH. Prevention of biofilm formation and removal of existing biofilms by extracellular DNases of Campylobacter jejuni. PLoS One. 2015 Mar 24;10(3):e0121680. doi: 10.1371/journal.pone.0121680. PMID: 25803828; PMCID: PMC4372405.
Rendueles O, Ghigo JM. Multi-species biofilms: how to avoid unfriendly neighbors. FEMS Microbiol Rev. 2012 Sep;36(5):972-89. doi: 10.1111/j.1574-6976.2012.00328.x. Epub 2012 Mar 8. PMID: 22273363.
Tram G, Day CJ, Korolik V. Bridging the Gap: A Role for Campylobacterjejuni Biofilms. Microorganisms. 2020 Mar 23;8(3):452. doi: 10.3390/microorganisms8030452. PMID: 32210099; PMCID: PMC7143964.
Otsuka Y, Hagiya H, Takahashi M, Fukushima S, Maeda R, Sunada N, Yamada H, Kishida M, Fujita K, Otsuka F. Clinical characteristics of Campylobacter bacteremia: a multicenter retrospective study. Sci Rep. 2023 Jan 12;13(1):647. doi: 10.1038/s41598-022-27330-4. PMID: 36635328; PMCID: PMC9837072.
Wakerley BR, Yuki N. Risk of guillain–barré syndrome from fresh chicken in the United Kingdom. Journal of Acute Medicine. 2016;6(4):105-106. doi: 10.1016/j.jacme.2016.09.002.
Nyati KK, Nyati R. Role of Campylobacter jejuni infection in the pathogenesis of Guillain-Barré syndrome: an update. Biomed Res Int. 2013;2013:852195. doi: 10.1155/2013/852195. Epub 2013 Aug 13. PMID: 24000328; PMCID: PMC3755430.
Vucic S, Kiernan MC, Cornblath DR. Guillain-Barré syndrome: an update. J Clin Neurosci. 2009 Jun;16(6):733doi: 10.1016/j.jocn.2008.08.033. Epub 2009 Apr 7. PMID: 19356935.
Fischer GH, Paterek E. Campylobacter. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.
Fernández-Cruz A, Muñoz P, Mohedano R, Valerio M, Marín M, Alcalá L, Rodriguez-Créixems M, Cercenado E, Bouza E. Campylobacter bacteremia: clinical characteristics, incidence, and outcome over 23 years. Medicine (Baltimore). 2010 Sep;89(5):319-330. doi: 10.1097/MD.0b013e3181f2638d. PMID: 20827109.
Pacanowski J, Lalande V, Lacombe K, Boudraa C, Lesprit P, Legrand P, Trystram D, Kassis N, Arlet G, Mainardi JL, Doucet-Populaire F, Girard PM, Meynard JL; CAMPYL Study Group. Campylobacter bacteremia: clinical features and factors associated with fatal outcome. Clin Infect Dis. 2008 Sep 15;47(6):790-6. doi: 10.1086/591530. PMID: 18699745.
Spyromitrou-Xioufi P, Ntoulios G, Ladomenou F, Niotakis G, Tritou I, Vlachaki G. Miller Fisher Syndrome Triggered by Infections: A Review of the Literature and a Case Report. J Child Neurol. 2021 Aug;36(9):785-794. doi: 10.1177/0883073820988428. PMID: 34448412.
Berumen A, Lennon R, Breen-Lyles M, Griffith J, Patel R, Boxrud D, Decuir M, Farrugia G, Smith K, Grover M. Characteristics and Risk Factors of Post-Infection Irritable Bowel Syndrome After Campylobacter Enteritis. Clin Gastroenterol Hepatol. 2021 Sep;19(9):1855-1863.e1. doi: 10.1016/j.cgh.2020.07.033. Epub 2020 Jul 23. PMID: 32711045; PMCID: PMC8994162.
Jribi H, Sellami H, Mariam S, Smaoui S, Ghorbel A, Hachicha S, Benejat L, Messadi-Akrout F, Mégraud F, Gdoura R. Isolation and Identification of Campylobacter spp. from Poultry and Poultry By-Products in Tunisia by Conventional Culture Method and Multiplex Real-Time PCR. J Food Prot. 2017 Oct;80(10):1623-1627. doi: 10.4315/0362-028X.JFP-16-321. PMID: 28853632.
Elhadidy M, Ali MM, El-Shibiny A, Miller WG, Elkhatib WF, Botteldoorn N, Dierick K. Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases. PLoS One. 2020 Jan 17;15(1):e0227833. doi: 10.1371/journal.pone.0227833. PMID: 31951631; PMCID: PMC6968864.
Luangtongkum T, Jeon B, Han J, Plummer P, Logue CM, Zhang Q. Antibiotic resistance in Campylobacter: emergence, transmission and persistence. Future Microbiol. 2009 Mar;4(2):189-200. doi: 10.2217/17460913.4.2.189. PMID: 19257846; PMCID: PMC2691575.
Wieczorek K, Osek J. Antimicrobial resistance mechanisms among Campylobacter. Biomed Res Int. 2013;2013:340605. doi: 10.1155/2013/340605. Epub 2013 Jun 24. PMID: 23865047; PMCID: PMC3707206.