Covid-19 Research

Case Report

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Paraneoplastic Yellow Nail Syndrome: A Case Report

General Science    Start Submission

Alfano Franco*, Casoni GL and Papi A

Volume5-Issue10
Dates: Received: 2024-10-15 | Accepted: 2024-10-24 | Published: 2024-10-27
Pages: 1398-1402

Abstract

Yellow Nail Syndrome (YNS) is a rare clinical condition affecting multiple districts. Distinctive signs include nail abnormalities, pulmonary manifestations, and lymphedema. The aetiology is unknown; usually presents isolated or as a paraneoplasticsyndrome.

There is no established treatment and resolution is limited. Low dose azithromycin with mucolytics and long-acting muscarinic antagonist could improve the respiratory component of the YNS when present. Here we describe a case of paraneoplastic YNS presenting with cough, sputum, rhinosinusitis, and nail discoloration appearing after a recent history of breast cancer.

In a patient with an oncological history, nail abnormalities associated with pulmonary manifestations and/or lower limbs lymphedema, the diagnosis of paraneoplastic YNS should be considered.

FullText HTML FullText PDF DOI: 10.37871/jbres2028


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Copyright

© 2024 Franco A, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Franco A, Casoni GL, Papi A. Paraneoplastic Yellow Nail Syndrome: A Case Report. J Biomed Res Environ Sci. 2024 Oct 27; 5(10): 1398-1402. doi: 10.37871/jbres2028, Article ID: JBRES2028, Available at: https://www.jelsciences.com/articles/ jbres2028.pdf


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References


  1. Cheslock M, Harrington DW. Yellow Nail Syndrome. 2022 Sep 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32491692.
  2. Vignes S, Baran R. Yellow nail syndrome: a review. Orphanet J Rare Dis. 2017 Feb 27;12(1):42. doi: 10.1186/s13023-017-0594-4. PMID: 28241848; PMCID: PMC5327582.
  3. Maldonado F, Ryu JH. Yellow nail syndrome. Curr Opin Pulm Med. 2009 Jul;15(4):371-5. doi: 10.1097/MCP.0b013e32832ad45a. PMID: 19373089.
  4. Emerson PA. Yellow nails, lymphoedema, and pleural effusions. Thorax. 1966 May;21(3):247-53. doi: 10.1136/thx.21.3.247. PMID: 5914998; PMCID: PMC1019033.
  5. Kurin M, Wiesen J, Mehta AC. Yellow nail syndrome: a case report and review of treatment options. Clin Respir J. 2017 Jul;11(4):405-410. doi: 10.1111/crj.12354. Epub 2015 Sep 24. PMID: 26257383.
  6. Xu S, Wu X. Respiratory manifestation of yellow nail syndrome: a case report and literature review. J Int Med Res. 2021 Dec;49(12):3000605211063313. doi: 10.1177/03000605211063313. PMID: 34878939; PMCID: PMC8670787.
  7. D'Alessandro A, Muzi G, Monaco A, Filiberto S, Barboni A, Abbritti G. Yellow nail syndrome: does protein leakage play a role? Eur Respir J. 2001 Jan;17(1):149-52. doi: 10.1183/09031936.01.17101490. PMID: 11307745.
  8. Maldonado F, Tazelaar HD, Wang CW, Ryu JH. Yellow nail syndrome: analysis of 41 consecutive patients. Chest. 2008 Aug;134(2):375-381. doi: 10.1378/chest.08-0137. Epub 2008 Apr 10. PMID: 18403655.
  9. Thomas PS, Sidhu B. Yellow nail syndrome and bronchial carcinoma. Chest. 1987 Jul;92(1):191. doi: 10.1378/chest.92.1.191a. PMID: 3595241.
  10. Hoque SR, Mansour S, Mortimer PS. Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature. Br J Dermatol. 2007 Jun;156(6):1230-4. doi: 10.1111/j.1365-2133.2007.07894.x. Epub 2007 Apr 25. PMID: 17459037.
  11. Carnassale G, Margaritora S, Vita ML, Parisi AM, Congedo MT, Cusumano G, Granone PM. Lung cancer in association with yellow nail syndrome. J Clin Oncol. 2011 Mar 1;29(7):e156-8. doi: 10.1200/JCO.2010.31.8402. Epub 2010 Dec 13. PMID: 21149669.
  12. Iqbal M, Rossoff LJ, Marzouk KA, Steinberg HN. Yellow nail syndrome: resolution of yellow nails after successful treatment of breast cancer. Chest. 2000 May;117(5):1516-8. doi: 10.1378/chest.117.5.1516. PMID: 10807848.
  13. Piraccini BM, Urciuoli B, Starace M, Tosti A, Balestri R. Yellow nail syndrome: clinical experience in a series of 21 patients. J Dtsch Dermatol Ges. 2014 Feb;12(2):131-7. doi: 10.1111/ddg.12216. Epub 2013 Oct 18. PMID: 24134631.
  14. Gupta AK, Davies GM, Haberman HF. Yellow nail syndrome. Cutis. 1986 May;37(5):371-4. PMID: 3011360.
  15. Siegelman SS, Heckman BH, Hasson J. Lymphedema, pleural effusions and yellow nails: associated immunologic deficiency. Dis Chest. 1969 Aug;56(2):114-7. doi: 10.1378/chest.56.2.114. PMID: 5822545.
  16. Ginarte M, Monteagudo B, Toribio J. Yellow nail syndrome and lung lymphoma. Clin Exp Dermatol. 2004 Jul;29(4):432-3. doi: 10.1111/j.1365-2230.2004.01541.x. PMID: 15245553.
  17. Seve P, Thieblemont C, Dumontet C, Bouafia F, Arnaud P, Hequet O, Espinouse D, Salles G, Coiffier B. Skin lesions in malignancy. Case 3. Yellow nail syndrome in non-Hodgkin's lymphoma. J Clin Oncol. 2001 Apr 1;19(7):2100-1. doi: 10.1200/JCO.2001.19.7.2100. Erratum in: J Clin Oncol 2001 Jun 1;19(11):2972. Steve, P [corrected to Seve, P]; Coiffer, B [corrected to Coiffier, B]. PMID: 11283146.
  18. Stosiek N, Peters KP, Hiller D, Riedl B, Hornstein OP. Yellow nail syndrome in a patient with mycosis fungoides. J Am Acad Dermatol. 1993 May;28(5 Pt 1):792-4. doi: 10.1016/s0190-9622(09)80277-6. PMID: 8496432.
  19. Letheulle J, Deslée G, Guy T, Lebargy F, Jego P, Delaval P, Desrues B, Jouneau S. Le syndrome des ongles jaunes: présentation de cinq cas [The yellow nail syndrome: a series of five cases]. Rev Mal Respir. 2012 Mar;29(3):419-25. French. doi: 10.1016/j.rmr.2011.09.046. Epub 2012 Feb 15. PMID: 22440307.
  20. Emerson PA. Yellow nails, lymphoedema, and pleural effusions. Thorax. 1966 May;21(3):247-53. doi: 10.1136/thx.21.3.247. PMID: 5914998; PMCID: PMC1019033.
  21. Xu S, Wu X. Respiratory manifestation of yellow nail syndrome: a case report and literature review. J Int Med Res. 2021 Dec;49(12):3000605211063313. doi: 10.1177/03000605211063313. PMID: 34878939; PMCID: PMC8670787.
  22. Fujita T, Sakurai T, Miki Y, Tomita K, Nakamura T, Toyoda H, Nakamura H. [A case of yellow nail syndrome associated with fibrosarcoma of the skin successfully treated with pleurodesis]. Nihon Kokyuki Gakkai Zasshi. 2010 Mar;48(3):224-8. Japanese. PMID: 20387528.
  23. Guin JD, Elleman JH. Yellow nail syndrome. Possible association with malignancy. Arch Dermatol. 1979 Jun;115(6):734-5. PMID: 453878.
  24. Burrows NP, Jones RR. Yellow nail syndrome in association with carcinoma of the gall bladder. Clin Exp Dermatol. 1991 Nov;16(6):471-3. doi: 10.1111/j.1365-2230.1991.tb01240.x. PMID: 1806327.
  25. Mambretti-Zumwalt J, Seidman JM, Higano N. Yellow nail syndrome: complete triad with pleural protein turnover studies. South Med J. 1980 Aug;73(8):995-7. PMID: 7403938.
  26. Umer M, Vaidyanathan R, Nguyen NT, Shiddiky MJA. Circulating tumor microemboli: Progress in molecular understanding and enrichment technologies. Biotechnol Adv. 2018 Jul-Aug;36(4):1367-1389. doi: 10.1016/j.biotechadv.2018.05.002. Epub 2018 May 18. PMID: 29753882.
  27. Lambert EM, Dziura J, Kauls L, Mercurio M, Antaya RJ. Yellow nail syndrome in three siblings: a randomized double-blind trial of topical vitamin E. Pediatr Dermatol. 2006 Jul-Aug;23(4):390-5. doi: 10.1111/j.1525-1470.2006.00251.x. PMID: 16918641.


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