Schistosomiasis is endemic in both the central and upper river region of The Gambia. Two mass drug administrations of praziquantel did not stop the transmission of these infections. Most of the World Health Organization recommended approach to controlling schistosomiasis through Mass Drug Administration has not significantly reduced transmission. The best approach could be multifaceted which will be designed to explore in the context of implementation research approach in addressing this infection at one of the hot spots in the Gambia to enhance the attainment of the schistosomiasis elimination road map of 2030. The target population will be farmers engaged in rice growing in river sites and swampy areas, as well as fishermen. Most of whom are women who do their laundry around farmland water bodies or freshwater river sites. The data collected will be analyzed and interpreted to provide better understanding in the context of knowledge, attitudes and, practices of these nomadic communities regarding the risk factors involved with schistosomiasis transmission, control and prevention. Developed materials and awareness messages on the prevention and control of schistosomiasis will therefore be use for community engagement activities to increase awareness on the disease, improve health seeking behaviors and increase treatment uptake. Thus, this community-led intervention could help to reduce the prevalence of schistosomiasis in Upper and Lower Falladou Districts.